Endocrine Abstracts

Rationale and objectives: Validation of new therapeutic regimens in the treatment of hypertension, particularly in poorly controlled patients at high risk for cardiovascular disease, is urgently needed. We evaluated the efficacy and safety of two doses of the candesartan cilexetil/hydrochlorothiazide combination (Blopress Plus®) in hypertensive patients in Jordan.Methods: An observational, multicenter, prospective, open-label study of Jor...

Diabetes is a major health problem that affects 8.5% of adults worldwide, and 13.2% of adults in Jordan. Studies suggest a bidirectional relationship between diabetes and chronic depression. Diabetic patients are twice as likely to suffer from depression that is symptomatically worse when compared to nondiabetic individuals. Depressed diabetics suffer from poor glycemic control and increased risk of diabetes complications. Because little is known about the bidirectional relati...

Background: Prostate cancer is the second leading cause of cancer-related deaths in men worldwide. A marker of poor survival in prostate cancer patients is the loss of the tumor suppressor gene PTEN (phosphoinositide-3-phosphatase). Deletion of PTEN occurs in approximately 40% of prostate cancer patients, and is associated with early biochemical recurrence, metastatic potential, and androgen-independence. Androgen-deprivation-therapy (ADT) remains the princip...